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Search Results to Mamuka Kvaratskhelia

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One or more keywords matched the following items that are connected to Kvaratskhelia, Mamuka

Item TypeName
Concept Intercellular Signaling Peptides and Proteins
Academic Article A new class of multimerization selective inhibitors of HIV-1 integrase.
Academic Article LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.
Academic Article The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Academic Article The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Academic Article Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.
Academic Article Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.
Academic Article Molecular mechanisms of retroviral integration site selection.
Academic Article FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.
Academic Article HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.
Academic Article Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.
Academic Article A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.

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